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Acute Lymphoblastic Leukemia
Pediatric ALL Relapse Risk Linked to Extreme Poverty
A subanalysis of the AALL03N1 study shows reduced adherence to oral mercaptopurine in children with acute lymphoblastic leukemia who live in households with the lowest incomes. Here’s what else the research team discovered.
Young Cancer Survivors are at Risk for Major Psychiatric Disorders
Investigators in Taiwan conducted a nationwide longitudinal study to assess the risk of major psychiatric disorders in childhood survivors of cancer versus healthy controls. Their findings provide a revealing look at these associations.
Spontaneous Remission of ALL: What’s the Driving Factor?
A team of US investigators set out to elucidate the phenomenon of spontaneous remission in ALL, identifying a few possible underlying mechanisms.
CMV-Positive ALL, Maternal Infection During Pregnancy, and Childhood Infections
These investigators explored associations among early-life and in utero infections and cytomegalovirus-positive acute lymphoblastic leukemia in children, with signs pointing to underlying immune dysfunction.
Pediatric ALL and Congenital CMV: What Do We Know about a Possible Link?
Building on the conclusions of prior studies, a new analysis further explores the association between congenital cytomegalovirus infection and acute lymphoblastic leukemia in children.
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MRD in ALL: 2023 Update
ALL Therapies: Reasons for Optimism Moving Forward
Describing the benefits of combination therapies, Catherine Lai, MD, MPH, of the University of Pennsylvania, says that advances in ALL treatment "is an area that's very exciting." (0:58)
Children with ALL Still Have a High Mortality Rate, Despite Survival Improvements
This retrospective cohort study of Swedish national databases showed that, while it has been decreasing over time, the mortality rate of children with acute lymphoblastic leukemia was 40 times higher than that of the general population.
In ALL Patients, 5-year Survival was Similar for HCT with Matched Sibling and Matched Unrelated Donors
In GMALL trials 06/99 and 07/03, HCT performed with MUD cells was as safe and effective as HCT using MSD cells in this patient population, with a 5-year survival rate of approximately 58% in both groups. Prior studies on this topic were inconclusive.
Childhood ALL Survivors Have a Better Quality of Life Compared to the General Population
In a case-control study that assessed the quality of life of adult survivors of childhood acute lymphoblastic leukemia, survivors reported higher quality of life than controls in psychosocial functioning and did not report worse outcomes in physical functioning.