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Advances in Psoriatic Arthritis
PsA Biomarkers: Are They Viable?
Nilasha Ghosh, MD, MS, of the Hospital for Special Surgery, discusses the current status of biomarkers in psoriatic arthritis—an area that "unfortunately we just haven't really been able to nail down," she says. (1:24)
Approaching Multidomain PsA
Nilasha Ghosh, MD, MS, of the Hospital for Special Surgery and Weill Cornell Medicine, discusses how she treats psoriatic arthritis patients with multidomain involvement. (3:00)
Who Suffers More From Psoriatic Arthritis: Men or Women?
Although psoriatic arthritis is present in both sexes to a similar degree, researchers set out to determine whether the disease has a greater impact on clinical manifestations and quality of life in men versus women.
Early-Onset Versus Late-Onset Psoriasis: A New Data Analysis
What distinguishing demographic and clinical characteristics are there between patients who present before age 60 with psoriatic arthritis versus those diagnosed at age 60 or older? An international research team reported answers.
Early PsA Diagnosis: Can Circulating MicroRNA Patterns Help?
MicroRNA signatures were shown to differ between patients with psoriasis and psoriatic arthritis and may be able to aid in early detection in patients with psoriasis who might progress to psoriatic arthritis.
In PsA, Achieving Early Minimal Disease Activity May Improve Long-term Patient-Reported Outcomes
A Dutch study showed that patient-reported outcomes for those who achieved minimal disease activity were comparable to the general population after 2 (sustained) and 3 (non-sustained) years of follow-up.
Does Inflammatory Joint Disease Increase Preeclampsia Risk?
Rheumatoid arthritis, axial spondyloarthritis, and psoriatic arthritis have been linked to poorer outcomes during pregnancy, but not much is known about how these conditions raise the risk of preeclampsia, another potential danger to pregnant women.
Emerging Data on Isolated Axial Disease in PsA and Ankylosing Spondylitis with Psoriasis
Researchers in Canada compared isolated axial psoriatic arthritis, axial PsA with peripheral involvement, and isolated axial ankylosing spondylitis with psoriasis, to determine which factors predict who will develop which type of disease over time.
Challenges of a Treat-to-Target Approach in PsA
Dr. Orbai, of Johns Hopkins, describes the three main obstacles she sees in successfully implementing a treat-to-target approach. (4:19)
Do Psoriasis Patients Have an Increased Risk of Suicide?
Yes, say the results of a new study. And the risk of suicidality was higher in patients with psoriatic arthritis than in those who only had psoriasis.
Predicting the Risk of PsA in Patients with Psoriasis
These researchers used a novel screening model with multiple variables to predict psoriasis patients’ likelihood of eventually developing psoriatic arthritis. Here’s what they concluded.
Predicting Response to PsA Therapy: Beyond CRP?
Dr. Orbai, of Johns Hopkins, explains the importance of an experienced clinician. As far as reliable assessments go, "we have nothing," she says. (1:04)
In PsA, Novel Potential Contributions to Coronary Artery Disease
A recent study found elevated markers of metabolic and inflammatory disease in patients with PsA, compared with controls, suggesting novel targets for CVD prevention and treatment.
PsA and Obesity: Can Patients Lose Weight Without Muscle Deterioration?
Patients with both psoriatic arthritis and obesity may benefit from weight loss, but the muscle mass they’re likely to lose could have deleterious effects. A new study took a closer look at this clinical conundrum.
Does Atopic Dermatitis Open a Window to Other Autoimmune Diseases?
Yes, says a team of U.K.-based researchers who found that the risk of new-onset autoimmune disease was twice as high in people with more-severe atopic dermatitis (AD) compared to a group of matched controls.
Joint Involvement in Psoriasis: Increased Depression Burden
Investigators studied whether the presence of depression and lifetime suicidal ideation is associated with joint involvement in patients with psoriasis.
Patients with Autoimmune Inflammatory Rheumatic Diseases: Better COVID-19 Vaccinations Rates Needed
All patients with autoimmune inflammatory rheumatic diseases should be vaccinated against COVID-19, despite the risk of flares or other vaccine-related adverse events, say experts who recently convened (virtually) to discuss the topic.
Q&A: Guy Katz, MD, on Inflammatory Arthritis and Depression, Anxiety, Pain, or Opioid Use and TNF Inhibitor Persistence
What are the links among mood disorders and persistence with TNF inhibitors?
How Does COVID-19 Affect Outcomes in Patients with IMIDs?
Canadian researchers found higher rates of hospitalization for COVID-19 among patients with IMID than in those without IMIDs that were not solely explained by their demographics or comorbidities.
Psoriasis to PsA: What Drives the Transition?
A team at the Mayo Clinic recently analyzed clinical and demographic characteristics associated with the time to development of psoriatic arthritis (PsA) in patients with psoriasis. What they discovered may surprise you.
Methotrexate for Psoriatic Arthritis: When Patients Aren’t Compliant
Investigators in Italy recently found that about 50% of patients who are prescribed methotrexate to treat their psoriatic arthritis (PsA) eventually discontinue the medication. Further, one formulation is more than twice as likely to be skipped as the other one.
PsA and VTE: Untangling the Connection
The association between psoriatic arthritis (PsA) and venous thromboembolism (VTE) is related to underlying comorbidities, such as older age and a previous history of VTE, and not independently associated with PsA, say the results of a new study.
Q&A: Distinguishing Psoriatic Arthritis
William Saalfeld, DNP, APRN, discusses key aspects of diagnosing, treating, and monitoring psoriatic arthritis.
Inflammatory Rheumatic Diseases and Fatigue
The fatigue that often accompanies diseases including psoriatic arthritis and rheumatoid arthritis is complex, multifaceted, and still a puzzle, according to the authors of this review.
Psoriatic Arthritis, Even with Comorbidities, Does Not Increase Mortality Risk
Good news: A study involving a large cohort of patients with psoriatic arthritis found that their risk of death was no higher than in a matched population with the same comorbid conditions.
Which Psoriasis Characteristics Predict Psoriatic Arthritis?
Definitive answers to this question would help funnel the appropriate patients to appropriate rheumatologic care.
Rheum Tweets During a Pandemic
An international team of researchers found that many patients who struggle with rheumatic and musculoskeletal diseases use social media to express their concerns about how to manage their condition, especially now, in the face of a global pandemic.
Nail Disease in Psoriatic Arthritis
Nail psoriasis is a notable characteristic in many, but not all, patients with psoriatic arthritis. This study is an attempt to obtain more specific, detailed information about the connection between these conditions, as well as their implications.
When Psoriasis Patients Need a Rheumatology Referral-Yesterday
Psoriatic arthritis (PsA) can be managed more effectively if it’s caught early. Researchers in Germany sought to find clues to the development of PsA among a large database of patients with psoriasis. Here’s what they found.
In Psoriasis, Be Alert to Impaired Hand Function—Even in the Absence of Arthritis
German researchers compared grip strength and fine-motor skills in patients with psoriasis, psoriatic arthritis, and rheumatoid arthritis and healthy controls. There were surprises.
Psoriatic Arthritis and Sleep Problems, Fatigue, and Depression
A recent study examined the association between skin and musculoskeletal involvement and sleep, fatigue, and depression, and found the need to look beyond objective measures of disease activity.
In PsA, RA, and axSpA, Fatigue Hits Hard
Researchers in Denmark surveyed patients with RA, PsA, and axSpA to find correlations between fatigue and work impairment, physical function, and various quality of life measures.
Inflammatory Arthritis: COVID-19 Outcomes in Patients on DMARDs
This study attempted to answer a common question from patients with inflammatory arthritis at the outset of the COVID-19 pandemic: What do I do about my medications?
Migraine and Neuropathic Pain in Rheumatic Diseases: How Bad Is It?
French investigators found that patients with chronic inflammatory rheumatoid diseases (CIRDs) have twice the prevalence of migraine and more than 3 times the prevalence of neuropathic pain as the general population.
Q&A: The Link Between Obesity and Psoriatic Arthritis
Anand Kumthekar, MD, of Montefiore Medical Center and Albert Einstein College of Medicine in NYC, discusses how this dangerous association can be mitigated with weight loss and medication.
SLE Risk Elevated in Women with PsA
SLE prevalence may be nearly 3-fold higher in the female PsA patient population than the general population. These investigators identified possible risk factors.
Psoriasis, but Not Use of Biologics, Tied to Cancer Risk
A recent study examined the association between psoriasis and the risk of cancer. Alhough psoriasis was associated with a slightly increased risk for certain cancers, psoriatic arthritis and biologic therapies were not.
PsA: Characteristics of Persistent Liver Abnormalities
A case-control longitudinal cohort study reveals that 32% of psoriatic arthritis patients develop liver abnormalities within 14 years of diagnosis. These investigators assessed potential risk factors.