Anemia

In a phase III trial, momelotinib reduced anemia, constitutional symptoms, and splenomegaly

Commission lays out strategies for progress by 2025 and beyond

An analysis of the ASPREE trial showed 100-mg aspirin led to more anemia events vs placebo

Condition may exacerbate racial disparities in severe maternal morbidity

Results suggest a "paradigm shift" in the treatment of anemia for these patients

What effects might emerging therapies have on real-world survival?

Daprodustat is the first agent in new class of HIF-PHIs to gain FDA approval

Patients see reductions in spleen size, require fewer transfusions with momelotinib over danazol

But thumbs quickly turn down for the non-dialysis subset

Less than half of patients ages 2 to 16 undergo ultrasound to assess risk of stroke

Trial confirms higher rate of hypophosphatemia with ferric carboxymaltose

In small study, mitapivat increased hemoglobin in 80% of non-transfusion-dependent patients

COVID-19 severity strongly linked with sickle cell anemia as well

Mitapivat improved outcomes in "substantial minority" of patients with rare hereditary condition