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Focus on Advanced Breast Cancer
Assessing the Impact of BRCA Mutations on HR-Positive Metastatic Breast Cancer
A new study from France revealed adverse associations of BRCA mutations on patient outcomes, with notably lower survival rates for those receiving first-line endocrine therapy, emphasizing the need for more-effective therapeutic strategies for this subset of patients.
CNN-based AI Modeling: Can Morphometric Features in Invasive TNBC Predict NAC Response?
Exciting new technologies, including artificial intelligence (AI), are making their way into research to improve cancer diagnosis and treatment. A team of U.S.-based investigators is moving forward with a new tool for patients with triple-negative breast cancer.
Neoadjuvant Chemotherapy for Breast Cancer: Racial/Ethnic Differences Observed Among Outcomes
A large cohort of breast cancer patients receiving neoadjuvant chemotherapy was assessed to compare differences in pathological complete response rates among racial and ethnic groups.
PIK3CA Mutation Status and Survival in Metastatic Breast Cancer Patients
This meta-analysis links this mutation with shorter progression-free and overall survival.
Advanced Breast Cancer: The Challenges of Putting NGS Information to Good Use
Italian investigators determined the portion of patients with advanced breast cancer who may benefit from NGS analysis and targeted therapies, despite the difficulties in obtaining those agents in some parts of the world.
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Returning to Work After a Metastatic Breast Cancer Diagnosis
This cohort study performed at the Karolinska Institute examined factors most likely to predict successful return to work for more than 180 days the year after diagnosis with metastatic breast cancer.
Household Income, 21-Gene Recurrence Score, and Survival in Breast Cancer
The findings of this investigation from Roswell Park Comprehensive Cancer Center showed that more aggressive tumor biology and significantly shorter survival were linked with low household income, even in breast cancer with a better prognosis.